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Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease) and cirrhosis of the liver: A case report and literature review

Mpho Klaas Kgomo, Ali A Elnagar, Christian Jeske, Jackoo Nagel

Abstract


Patients with cirrhosis of the liver usually present with a small shrunken liver and a large spleen. The presence of an unusually huge liver should prompt the treating doctor to look for another cause, as this may be treatable and improve the patient’s outcome. In South Africa tuberculosis and lymphoma in the presence of HIV infection should be excluded. Sinus histiocytosis with massive lymphadenopathy and cirrhosis is a rare combination and has not been reported before in the literature. This case is intended to make clinicians aware of this rare combination of diseases.

Authors' affiliations

Mpho Klaas Kgomo, Gastroenterology Division of Internal Medicine, Steve Biko Academic Hospital and School of Medicine, Faculty of Health Sciences, University of Pretoria, South Africa

Ali A Elnagar, Gastroenterology Division of Internal Medicine, Steve Biko Academic Hospital and School of Medicine, Faculty of Health Sciences, University of Pretoria, South Africa

Christian Jeske, Gastroenterology Division of Surgery, Steve Biko Academic Hospital and School of Medicine, Faculty of Health Sciences, University of Pretoria, South Africa

Jackoo Nagel, Gastroenterology Division of Internal Medicine, Steve Biko Academic Hospital and School of Medicine, Faculty of Health Sciences, University of Pretoria, South Africa

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Keywords

Sinus histiocytosis; Massive lymphadenopathy; Rosai-Dorfman disease; Cirrhosis of the liver

Cite this article

South African Medical Journal 2016;106(5):463-464. DOI:10.7196/SAMJ.2016.v106i5.9614

Article History

Date submitted: 2015-03-17
Date published: 2016-03-30

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