Original articles

Cryptococcus and Lymphocytic Meningitis In Botswana

Gregory Bisson, John Lukes, Isaac Mtoni, Rob Roy MacGregor


We retrospectively reviewed microbiology data from a tertiary care hospital in Botswana and found that Cryptococcus neoformans was cultured from 15% (193/1307) of all cerebrospinal (CSF) fluid specimens submitted for analysis, making it the most common diagnosed cause of meningitis in this population. Moreover, almost 70% of CSF samples with significant lymphocytosis did not yield a pathogen, suggesting that many causes of lymphocytic meningitis are going undiagnosed.

Authors' affiliations

Gregory Bisson,

John Lukes, Department of Psychology, University of San Diego, San Diego, California

Isaac Mtoni, National Health Laboratory, Gaborone

Rob Roy MacGregor, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania

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Cryptococcus; epidemiology; opportunistic infections

Cite this article

South African Medical Journal 2008;98(9):724.

Article History

Date submitted: 2008-04-05
Date published: 2008-08-06

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