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Asthma treatment in children: A guide to screening for and management of hypothalamic-pituitary-adrenal axis suppression

E W Zöllner


A recently published approach to paediatric asthma management neither recommended screening for nor suggested any management of hypothalamic-pituitary-adrenal axis suppression in asthmatic children treated with corticosteroids. The existing literature on this topic was therefore reviewed and the quality of the evidence assessed. Recommendations for diagnosis, screening and management are made utilising the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach.

Author's affiliations

E W Zöllner, Endocrine Unit, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa

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Asthma; Adrenal insufficiency; Steroids/adverse effects; Pituitary-adrenal-function tests; Children

Cite this article

South African Medical Journal 2019;109(5):306-309. DOI:10.7196/SAMJ.2019.v109i5.13932

Article History

Date submitted: 2019-04-29
Date published: 2019-04-29

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