Review

Pre-exposure prophylaxis for South African adolescents: What evidence?

L-G Bekker, K Gill, M Wallace

Abstract


Adolescents and young women, particularly in South Africa, are at increased risk of HIV acquisition. To date, we have had limited primary prevention options to offer. Oral pre-exposure prophylaxis (PrEP) is an additional prevention modality that has now been proven to reduce HIV acquisition in those who take it consistently during periods of HIV infection exposure. We review the PrEP evidence in adolescents and highlight some of the research gaps. Our recommendation is to increase the number of demonstration projects and other scale-up opportunities to offer oral PrEP to at-risk adolescents, and monitor carefully to answer the outstanding questions. 


Authors' affiliations

L-G Bekker, Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa

K Gill, Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa

M Wallace, Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa

Full Text

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Keywords

HIV; Pre-exposure prophylaxis; PrEP; Adolescents; South Africa

Cite this article

South African Medical Journal 2015;105(11):907-911. DOI:10.7196/SAMJ.2015.v105i11.10222

Article History

Date submitted: 2015-10-19
Date published: 2015-10-19

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