Continuing Medical Education

An additional X chromosome

M C Madua


A 35-year-old man presented with symmetrical inflammatory polyarthritis of the small and large joints and associated early-morning stiffness. He was assessed as having features in keeping with Klinefelter’s syndrome. It is evident from the literature that there is a relationship between Klinefelter’s syndrome and developing rheumatic conditions.


Author's affiliations

M C Madua, Charlotte Maxeke Johannesburg Academic Hospital, and Division of Rheumatology, Department of Internal Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa

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Klinefelter's syndrome

Cite this article

South African Medical Journal 2015;105(2):156. DOI:10.7196/SAMJ.9266

Article History

Date submitted: 2014-12-08
Date published: 2014-12-22

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