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Prevalence of and risk factors for retinopathy of prematurity in a cohort of preterm infants treated exclusively with non-invasive ventilation in the first week after birth

S K van der Merwe, N Freeman, A Bekker, J Harvey, J Smith

Abstract


Objectives. To determine the current prevalence of retinopathy of prematurity (ROP) in premature babies treated with non-invasive ventilation at Tygerberg Children’s Hospital, Parow, Cape Town, South Africa, and to identify risk factors associated with the development of ROP.

Methods. A retrospective medical records review of infants screened for ROP during a 2-year period (January 2009 - December 2010). Infants who did not receive invasive ventilation during the first week of life were included. Twenty-four previously reported risk factors for the development of ROP were identified for use in a multivariate logistic regression (MLR) analysis.

Results. A total of 356 patients were included. The overall prevalence of ROP was 21.8% and that of clinically significant ROP (CSROP) 4.4%. The risk factors with a statistically significant association with the development of ROP on MLR analysis were severe apnoea (p=0.0005) and decreasing birth weight (p=0.0382).

Conclusions. There is a low prevalence of ROP in the cohort of preterm infants treated exclusively with non-invasive ventilation in the first week of life. The risk factors of importance in our population were severe apnoea and lower birth weight. Birth weight is a practical and reproducible variable that can be used to aid development of ROP screening criteria.

Authors' affiliations

S K van der Merwe, Tygerberg Children’s Hospital and Department of Paediatrics, Stellenbosch University, Parow, Cape Town

N Freeman, Tygerberg Children’s Hospital and Department of Paediatrics, Stellenbosch University, Parow, Cape Town

A Bekker, Tygerberg Children’s Hospital and Department of Paediatrics, Stellenbosch University, Parow, Cape Town

J Harvey, Faculty of Medicine and Health Sciences, Stellenbosch University, Parow, Cape Town

J Smith, Tygerberg Children’s Hospital and Department of Paediatrics, Stellenbosch University, Parow, Cape Town

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Keywords

retinopathy of prematurity; prematurity complications; oxygen; NCPAP; TCH

Cite this article

South African Medical Journal 2013;103(2):96-100. DOI:10.7196/SAMJ.6131

Article History

Date submitted: 2012-07-13
Date published: 2013-01-14

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