Research

Extremely high prevalence of multi-resistance among uropathogens from hospitalised children in Beira, Mozambique

Birgitta Theodora van der Meeren, Kajal D Chhaganlal, Annett Pfeiffer, Ermelinda Gomez, Josefo J Ferro, Mirrian Hilbink, Cesar Macome, Francien J van der Vondervoort, Konrad Steidel, Peter C Wever

Abstract


Objectives. A prospective surveillance study was conducted to investigate the epidemiology and patterns of antibiotic resistance among uropathogens from hospitalised children in Beira, Mozambique. Additionally, information regarding determinants of a urinary tract infection (UTI) was obtained. 

Methods. Bacterial species identification, antimicrobial susceptibility testing and extended-spectrum beta-lactamase testing were performed for relevant bacterial isolates. 

Results. Analysis of 170 urine samples from 148 children yielded 34 bacterial isolates, predominantly Escherichia coli and Klebsiella spp., causative of a urinary tract infection in 29 children; 30/34 isolates (88.2%) from 26/29 children (89.7%) were considered highly resistant micro-organisms (HRMOs). No significant determinants of urinary tract infection with HRMOs were detected when analysing gender, antibiotic use during hospital admission and HIV status. 

Conclusion. This study shows, for the first time in Mozambique, an extremely high prevalence of HRMOs among uropathogens from hospitalised children with a urinary tract infection.


Authors' affiliations

Birgitta Theodora van der Meeren, Universidade Católica de Moçambique, Beira, Mozambique; Department of Medical Microbiology and Infection Control, Jeroen Bosch Hospital, ’s-Hertogenbosch

Kajal D Chhaganlal, Hospital Central da Beira, Beira, Mozambique

Annett Pfeiffer, Universidade Católica de Moçambique, Beira, Mozambique

Ermelinda Gomez, Hospital Central da Beira, Beira, Mozambique

Josefo J Ferro, Universidade Católica de Moçambique, Beira, Mozambique

Mirrian Hilbink, Jeroen Bosch Academy, Jeroen Bosch Hospital, ’s-Hertogenbosch, The Netherlands

Cesar Macome, Hospital Central da Beira, Beira, Mozambique

Francien J van der Vondervoort, Department of Medical Microbiology and Infection Control, Jeroen Bosch Hospital, ’s-Hertogenbosch, The Netherlands

Konrad Steidel, Universidade Católica de Moçambique, Beira, Mozambique

Peter C Wever, Department of Medical Microbiology and Infection Control, Jeroen Bosch Hospital, ’s-Hertogenbosch, The Netherlands

Full Text

PDF (122KB) HTML

Keywords

uropathogens in children; antimicrobial resistance patterns; highly resistant microorganisms; high antibiotic usage; Mozambique

Cite this article

South African Medical Journal 2013;103(6):382-386. DOI:10.7196/SAMJ.5941

Article History

Date submitted: 2012-04-20
Date published: 2013-03-15

Article Views

Abstract views: 1236
Full text views: 2667

Comments on this article

*Read our policy for posting comments here