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The spread of carbapenem-resistant Enterobacteriaceae in South Africa: Risk factors for acquisition and prevention

Adrian Brink, Jennifer Coetzee, Cornelis Clay, Craig Corcoran, Johan van Greune, J D Deetlefs, Louise Nutt, Charles Feldman, Guy Richards, Patrice Nordmann, Laurent Poirel

Abstract


New, effective antibiotics are only likely to become available in 15 - 20 years. To prevent deaths from untreatable Gram-negative infections in South Africa, the rights of any doctor, whether in general or in hospital practice, to indiscriminately prescribe whatever antibiotic they wish, and in whatever fashion, must be challenged. Furthermore, although prevention of the emergence and subsequent spread of carbapenem-resistant Enterobacteriaceae (CRE) has focused on acute and chronic care facilities and inter alia on antibiotic exposure in these institutions, CRE may soon become an issue within entire communities, highlighting a role for public health authorities in CRE prevention efforts.

Authors' affiliations

Adrian Brink, Department of Clinical Microbiology, Ampath National Laboratory Services, Milpark Hospital, Johannesburg

Jennifer Coetzee, Department of Clinical Microbiology and Molecular Biology, Ampath National Laboratory Services, National Referral Laboratory, Centurion, Gauteng

Cornelis Clay, Department of Clinical Microbiology and Molecular Biology, Ampath National Laboratory Services, National Referral Laboratory, Centurion, Gauteng

Craig Corcoran, Department of Clinical Microbiology and Molecular Biology, Ampath National Laboratory Services, National Referral Laboratory, Centurion, Gauteng

Johan van Greune, Ampath National Laboratory Services, Cape Town

J D Deetlefs, Ampath National Laboratory Services, Cape Town

Louise Nutt, Ampath National Laboratory Services, Port Elizabeth

Charles Feldman, Department of Critical Care and Division of Pulmonology, Charlotte Maxeke Johannesburg Academic Hospital, and University of the Witwatersrand, Johannesburg

Guy Richards, Department of Critical Care and Division of Pulmonology, Charlotte Maxeke Johannesburg Academic Hospital, and University of the Witwatersrand, Johannesburg

Patrice Nordmann, Service de Bacteriologie-Virologie, Hospital de Bicetre, Assistance Publique/Hopitaux de Paris, Faculte de Medecine et Universite Paris-Sud, K-Bicetre

Laurent Poirel, Service de Bacteriologie-Virologie, Hospital de Bicetre, Assistance Publique/Hopitaux de Paris, Faculte de Medecine et Universite Paris-Sud, K-Bicetre

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Keywords

Carbapenem resistant Enterobacteriaceae; antibiotic stewardship

Cite this article

South African Medical Journal 2012;102(7):599-601.

Article History

Date submitted: 2012-03-01
Date published: 2012-05-10

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