Centenary of the UCT Faculty of Health Sciences
Shedding the load of hypertension: The proteolytic processing of angiotensin-converting enzyme
A number of membrane proteins are enzymatically cleaved or ‘shed’ from the cell surface, resulting in the modulation of biological events and opening novel pharmaceutical approaches to diverse diseases by targeting shedding. Our focus has been on understanding the shedding of angiotensin-converting enzyme (ACE), an enzyme that plays a pivotal role in blood pressure regulation. The identification of novel hereditary ACE mutations that result in increased ACE shedding has advanced our understanding of the role of ACE shedding in health and disease. Extensive biochemical and molecular analysis has helped to elucidate the mechanism of ACE shedding. These findings point to the potential therapeutic role of targeting shedding in regulating tissue ACE levels in cardiovascular disease.
Mario R W Ehlers, Clinical Trials Group, Immune Tolerance Network
Kerry Gordon, Department of Molecular and Cell Biology, University of Cape Town
Sylva L U Schwager, University of Cape Town
Edward D Sturrock, Department of Medical Biochemistry, University of Cape Town
Angiotensin-Converting Enzyme; Ectodomain Shedding; Sheddase; Cardiovascular Disease; ADAM, Metalloprotease
Cite this article
South African Medical Journal 2012;102(6):461-464.
Date submitted: 2012-01-13
Date published: 2012-03-02
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