Centenary of the UCT Faculty of Health Sciences

Inflammatory pathways in cervical cancer – the UCT contribution

Kurt Jason Sales, Arieh Anthony Katz

Abstract


Cervical cancer is the leading gynaecological malignancy in Southern Africa. The main causal factor for development of the disease is infection of the cervix with human papillomavirus. It is a multi-step disease with several contributing co-factors including multiple sexual partners, a compromised immune system and cervical inflammation caused by infections with Chlamydia trachomatis or Neisseria gonorrhoeae. Inflammation involves extensive tissue remodelling events which are orchestrated by complex networks of cytokines, chemokines and bio-active lipids working across multiple cellular compartments to maintain tissue homeostasis. Many pathological disorders or diseases, including cervical cancer, are characterised by the exacerbated activation and maintenance of inflammatory pathways. In this review we highlight our findings pertaining to activation of inflammatory pathways in cervical cancers, addressing their potential role in pathological changes of the cervix and the significance of these findings for intervention strategies.

Authors' affiliations

Kurt Jason Sales, Institute of Infectious Disease and Molecular Medicine and Division of Medical Biochemistry, University of Cape Town

Arieh Anthony Katz, Institute of Infectious Disease and Molecular Medicine and Division of Medical Biochemistry, University of Cape Town

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Keywords

Inflammation, cyclooxygenase, prostaglandin, seminal fluid, cervical cancer, HPV, HIV

Cite this article

South African Medical Journal 2012;102(6):493-496.

Article History

Date submitted: 2011-12-14
Date published: 2012-03-23

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