Guidelines

Paediatric anticoagulation guidelines

Elise Schapkaitz, Gayle Gillian Sherman, Barry Frank Jacobson, Sylvia Haas, Harry R Buller, Victor Davies, Hitesh Diar, Marjolein Peters, Margaret Shuttleworth, Sithembiso Velaphi

Abstract


Prepared on behalf of the South African Society of Thombosis and Haemostasis.
Background. Recent progress has been made in the understanding of venous thrombo-embolism (VTE) in children and neonates; however, indications for laboratory investigations and therapeutic interventions are not well defined.
Method. The Southern African Society of Thrombosis and Haemostasis reviewed available literature and comprehensive evidence-based guidelines for paediatric antithrombotic therapy. A draft document was produced and revised by consensus agreement. The guidelines were adjudicated by independent international experts to avoid local bias.
Results and conclusion. We present concise, practical guidelines for the clinical management and laboratory investigation of VTE in children and neonates. Recommendations reflect current best practice which will hopefully lead to improved anticoagulation practice in this age group.

Authors' affiliations

Elise Schapkaitz, National Health Laboratory Services, and Department of Haematology, , University of the Witwatersrand, Johannesburg

Gayle Gillian Sherman, National Health Laboratory Services, and Department of Haematology, , University of the Witwatersrand, Johannesburg

Barry Frank Jacobson, National Health Laboratory Services, and Department of Haematology, , University of the Witwatersrand, Johannesburg

Sylvia Haas, Institute for Experimental Oncology and Therapy Research, Technical University of Munich, Germany

Harry R Buller, Department of Vascular Medicine, Academic Medical Centre, University of Amsterdam, The Netherlands

Victor Davies, Department of Paediatrics and Child Health, University of the Witwatersrand, Johannesburg

Hitesh Diar, Department of Paediatrics and Child Health, University of the Witwatersrand, Johannesburg

Marjolein Peters, Department of Vascular Medicine, Academic Medical Centre, University of Amsterdam, The Netherlands

Margaret Shuttleworth, Department of Haematology, Red Cross Children’s Hospital, University of Cape Town, Cape Town

Sithembiso Velaphi, Department of Paediatrics and Child Health, University of the Witwatersrand, Johannesburg

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Keywords

Thrombosis; Children and neonates

Cite this article

South African Medical Journal 2012;102(3):171-175.

Article History

Date submitted: 2011-11-23
Date published: 2012-02-23

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