Research

Phadiatop testing in assessing predisposition to respiratory tract symptoms of allergic origin in athletes

Anton H de Waard, Edith M Peters

Abstract


Objectives. To validate the use of the Phadiatop test as a predictor of allergy-associated respiratory tract symptoms (RTS) in trail runners.
Methods. The incidence of self-reported RTS was documented
in 16 runners for 31 days and related to the Phadiatop status and
circulating markers of allergic responses (changes in concentrations of serum IgE (sIgE), differential leucocyte counts) at 8 time points before, during and after a 3-day 95 km trail run.
Results. Twelve (75%) athletes, of whom 7 (58%) were Phadiatoppositive, presented with post-race RTS. A peak sIgE concentration >100 IU/ml accompanied RTS in only 4 (57%) of the symptomatic Phadiatop-positive subjects. There was no significant difference between the eosinophil and basophil concentrations of the positive and negative groups (p>0.05). One Phadiatop-negative subject presented with RTS as well as a peak sIgE concentration >100 IU/ml.
Conclusion. The Phadiatop assay does not accurately predict the
development of post-exercise RTS of allergic origin in trail runners.

Authors' affiliations

Anton H de Waard, Division of Human Physiology, School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban

Edith M Peters, Division of Human Physiology, School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban

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Keywords

Phadiotop® testing, allergy, respiratory tract symptoms, endurance athletes

Cite this article

South African Medical Journal 2012;102(5):309-311.

Article History

Date submitted: 2011-11-01
Date published: 2012-03-22

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