The rational use of systemic isotretinoin: A call for moderation

Werner Sinclair


Systemic isotretinoin effectively treats all forms of acne vulgaris. However, it has many side-effects, some potentially serious, that warrant limiting its use to serious cases of acne. Inappropriate use in large numbers of patients puts prescribers at risk of malpractice litigation should serious side-effects occur where safer alternative treatments were available. Doctors also risk losing access to the drug should authorities limit its use to reduce the occurrence of side-effects.

Author's affiliations

Werner Sinclair, Department of Dermatology Faculty of Health Sciences, University of the Free State, Bloemfontein

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Acne; isotretinoin;guidelines;

Cite this article

South African Medical Journal 2012;102(5):282-284.

Article History

Date submitted: 2011-09-22
Date published: 2012-03-21

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