Determinants of mortality in Nigerian children with severe anaemia
Objectives.To examine the pattern and predictors of mortality among severely anaemic children.
Methods. A prospective cross-sectional study was conducted among children with severe anaemia at the Children’s Emergency Room of the University Teaching Hospital, Ado-Ekiti, Nigeria. Socio-demographic characteristics, clinical features, laboratory findings and co-morbidities of the survivors and those who died were compared by logistic regression analysis.
Results. Of the 1 735 children admitted, 311 (17.9%) had severe anaemia, with a case - fatality rate of 9.3%. The presence of respiratory distress (95% confidence interval (CI) 2.1 - 3.6, p=0.031); acidosis (95% CI 1.8 - 2.7, p=0.010); coma (95% CI 0.1 - 0.3, p=0.001); hypotension (95% CI 2.0 - 4.2, p=0.020); and bacteraemia (95% CI 3.1 - 3.9; p=0.008) were the significant independent predictors of death with regression analysis.
Conclusion. Early recognition with prompt and appropriate anticipatory intervention is essential to reduce mortality from severe anaemia.
Samuel Adegoke, Department of Paediatrics and Child Health, Obafemi Awolowo University, Ile-Ife
Adenike Ayansanwo, Department of Haematology, University Teaching Hospital, Ado-Ekiti
Isaac Oluwayemi, Department of Paediatrics, University Teaching Hospital, Ado-Ekiti
John Okeniyi, Department of Paediatrics and Child Health, Obafemi Awolowo University, Ile-Ife
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Date published: 2012-08-20
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