A historical review of XDR tuberculosis in the Western Cape province of South Africa
Gregory Symons, Karen Shean, Elize Pietersen, Richard van Zyl Smit, Lititia Pool, Malika Davids, Paul Willcox, Keertan Dheda
There are limited data on the temporal relationship between the regional introduction of multidrug-resistant tuberculosis (MDR-TB) treatment and the subsequent development of extensively drug-resistant TB (XDR-TB). The first XDR-TB case in the Western Cape province of South Africa was recorded in 1992, approximately 5 - 7 years after the regional introduction of MDR-TB-like treatment. Between 1990 and 2002 we identified 48 patients with XDR-TB in the Cape Metropole region of the Western Cape province. Patients were predominantly HIV-uninfected and median survival was 10.8 months. XDR-TB has therefore been present in the Western Cape at least since 1992. These data inform public health policy relevant to the introduction of new anti-TB drug regimens.
Gregory Symons, UCT Lung Institute, GSH Department of Medicine
Richard van Zyl Smit,
Drug-resistant TB, XDR TB, South Africa, History
Cite this article
South African Medical Journal 2011;101(9):636,638.
Date submitted: 2011-07-26
Date published: 2011-09-05
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