A historical review of XDR tuberculosis in the Western Cape province of South Africa
There are limited data on the temporal relationship between the regional introduction of multidrug-resistant tuberculosis (MDR-TB) treatment and the subsequent development of extensively drug-resistant TB (XDR-TB). The first XDR-TB case in the Western Cape province of South Africa was recorded in 1992, approximately 5 - 7 years after the regional introduction of MDR-TB-like treatment. Between 1990 and 2002 we identified 48 patients with XDR-TB in the Cape Metropole region of the Western Cape province. Patients were predominantly HIV-uninfected and median survival was 10.8 months. XDR-TB has therefore been present in the Western Cape at least since 1992. These data inform public health policy relevant to the introduction of new anti-TB drug regimens.
Gregory Symons, UCT Lung Institute, GSH Department of Medicine
Richard van Zyl Smit,
Drug-resistant TB, XDR TB, South Africa, History
Cite this article
South African Medical Journal 2011;101(9):636,638.
Date submitted: 2011-07-26
Date published: 2011-09-05
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