Treatment of trichomoniasis in pregnancy in sub-Saharan Africa does not appear to be associated with low birth weight or preterm birth
Design. Sub-analysis of a randomised trial.
Setting. We analysed data from HPTN 024, a randomised trial of antenatal and intrapartum antibiotics to reduce chorioamnionitis-related perinatal HIV transmission.
Subjects. Pregnant women from four sites in Africa.
Outcome measures. Gestational age at the time of delivery or mean birth weight.
Results. Of 2 428 women-infant pairs included, 428 (18%) had trichomoniasis at enrolment. There were no differences in infant age or birth weight between women with or without trichomoniasis. By randomisation group, there were no differences in gestational age at birth or birth weight. Of the 428 women diagnosed with trichomoniasis, 365 (83%) received antibiotics and 63 (15%) did not. In analysis of actual use of antibiotics, women with trichomoniasis who received no treatment were more likely to deliver a preterm infant when the symphysis-fundal height was used to estimate gestational age (36% v. 23%; p=0.03), but not when the Ballard score was used (16% v. 21%; p=0.41). There were no differences in mean birth weight between groups.
Conclusions. In pregnant women in sub-Saharan Africa, most of whom were HIV-infected, neither trichomoniasis nor its treatment appears to influence the risk of preterm birth or a low-birth-weight infant.
Elizabeth Stringer, University of Alabama at Birmingham, Department of Obstetrics & Gynecology, Birmingham, AL, Centre for Infectious Disease Research in Zambia, Lusaka, Zambia
Jennifer S Read, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD
Irving Hoffman, University of North Carolina, Department of Medicine, Chapel Hill, NC
Megan Valentine, Family Health International, Durham, NC
Said Aboud, Muhimbili University of Health and Allied Sciences, Department of Microbiology and Immunology, Dar es Salaam, Tanzania
Robert L Goldenberg, Department of Obstetrics and Gynecology, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA
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Date published: 2010-01-13
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