Original articles

HIV prevention responsibilities in HIV vaccine trials: Complexities facing South African researchers

Zaynab Essack, Catherine Slack, Jennifer Koen, Glenda Gray

Abstract


Researchers should protect the welfare of research participants through providing methods to reduce their risk of acquiring HIV. This is especially important given that late-phase HIV vaccine trials enrol HIV-uninfected trial volunteers from high-risk populations.

Current ethical guidelines may be difficult for stakeholders to implement, and we know very little about what prevention services researchers are currently providing to participants or their successes, best practices and challenges. We recommend that current normative guidance be systematically reviewed and actual practice at vaccine sites be documented.

Adding new tools to the current package of prevention services will involve complex decision making with few set standards, and regulatory and scientific challenges. We recommend that stakeholders (including regulators) convene to consider standards of evidence for new tools, and that decision-making processes be explicitly documented and researched. A further critical ethical task is exploring the threshold at which adding new tools will compromise the validity of trial results.

Authors' affiliations

Zaynab Essack, HIV AIDS Vaccines Ethics Group (HAVEG), School of Psychology, University of KwaZulu-Natal, Pietermaritzburg

Catherine Slack, HIV AIDS Vaccines Ethics Group (HAVEG), School of Psychology, University of KwaZulu-Natal, Pietermaritzburg

Jennifer Koen, HIV AIDS Vaccines Ethics Group (HAVEG), School of Psychology, University of KwaZulu-Natal, Pietermaritzburg

Glenda Gray, HIV AIDS Vaccine Division, Perinatal HIV Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Gauteng, South Africa

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Keywords

Standard of prevention; HIV vaccine trials

Cite this article

South African Medical Journal 2010;100(1):45-48.

Article History

Date submitted: 2009-04-21
Date published: 2010-01-13

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