HIV prevention responsibilities in HIV vaccine trials: Complexities facing South African researchers
Current ethical guidelines may be difficult for stakeholders to implement, and we know very little about what prevention services researchers are currently providing to participants or their successes, best practices and challenges. We recommend that current normative guidance be systematically reviewed and actual practice at vaccine sites be documented.
Adding new tools to the current package of prevention services will involve complex decision making with few set standards, and regulatory and scientific challenges. We recommend that stakeholders (including regulators) convene to consider standards of evidence for new tools, and that decision-making processes be explicitly documented and researched. A further critical ethical task is exploring the threshold at which adding new tools will compromise the validity of trial results.
Zaynab Essack, HIV AIDS Vaccines Ethics Group (HAVEG), School of Psychology, University of KwaZulu-Natal, Pietermaritzburg
Catherine Slack, HIV AIDS Vaccines Ethics Group (HAVEG), School of Psychology, University of KwaZulu-Natal, Pietermaritzburg
Jennifer Koen, HIV AIDS Vaccines Ethics Group (HAVEG), School of Psychology, University of KwaZulu-Natal, Pietermaritzburg
Glenda Gray, HIV AIDS Vaccine Division, Perinatal HIV Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Gauteng, South Africa
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Date published: 2010-01-13
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