Hospital and community isolates of uropathogens at a tertiary hospital in South Africa
Out of the total specimens (n=2203) received over the one year study period, 51.1% (1126) of the urine samples were culture positive, the majority (65.4%) being from females. The commonest isolate was Escherichia coli (39.0%) followed by Klebsiella species (20.8%) and Enterococcus faecalis (8.2%). The Gram-negative isolates displayed a very high level of resistance to amoxicillin (range 43% – 100%) and co-trimoxazole (range 29% - 90%), whereas resistance to gentamicin (range 0% - 50%) and ciprofloxacin (range 0% - 33%) was lower. E coli isolates were susceptible to nitrofurantoin (94%) and ESBL production was significantly higher (p = 0.01) in the hospital isolates compared to those from the community referral sites.
The culture positive rate for uropathogens was high with the majority being from females. E coli was the commonest aetiological agent identified and remains susceptible to nitrofurantoin. Resistance levels to amoxicillin and co-trimoxazole are very high for all Gram negative isolates and it is recommended that these antibiotics should not be used for the empiric treatment of urinary tract infections.
Samukeliso Dube, University of Limpopo
Nazir Ismail, University of Pretoria
Anwar Ahmed Hoosen, University of Pretoria
Full TextPDF (453KB)
Cite this article
Date published: 2009-08-06
Full text views: 970