In Practice

Complete resolution of apparently definite radiological and histological usual interstitial pneumonia

D Simon, E M Irusen, B W Allwood, J Rigby, C F N Koegelenberg

Abstract


Idiopathic pulmonary fibrosis is considered to be the most common form of pulmonary fibrosis. It is a progressive and irreversible disease with a reported median survival of ~3 years. The pathological correlate is usual interstitial pneumonia (UIP), and although antifibrotic agents can slow down lung function decline, they do not completely reverse the disease process. To date, there have been no case reports describing reversal of UIP. We present a case where both the imaging and histology were compatible with definite UIP, yet it reversed with immunosuppressive therapy without the use of antifibrotic agents.


Authors' affiliations

D Simon, Division of Pulmonology, Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University and Tygerberg Academic Hospital, Cape Town, South Africa

E M Irusen, Division of Pulmonology, Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University and Tygerberg Academic Hospital, Cape Town, South Africa

B W Allwood, Division of Pulmonology, Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University and Tygerberg Academic Hospital, Cape Town, South Africa

J Rigby, Division of Anatomical Pathology, Department of Pathology and National Health Laboratory Service, Faculty of Medicine and Health Sciences, Stellenbosch University and Tygerberg Academic Hospital, Cape Town, South Africa

C F N Koegelenberg, Division of Pulmonology, Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University and Tygerberg Academic Hospital, Cape Town, South Africa

Full Text

PDF (1536KB)

Keywords

Medicine; Pulmonology; Hypersensitivity; Pneumonitis; Pulmonary fibrosis; South Africa; Case report

Cite this article

South African Medical Journal 2018;108(9):726-728. DOI:10.7196/SAMJ.2018.v108i9.13335

Article History

Date submitted: 2018-08-30
Date published: 2018-08-30

Article Views

Abstract views: 543
Full text views: 336

Comments on this article

*Read our policy for posting comments here