Molecular and cellular oncogenic mechanisms in hepatocellular carcinoma

M Setshedi, M Andersson, M M Kgatle, L Roberts


Hepatocellular carcinoma (HCC), as the fifth most diagnosed cancer in the world and the third leading cause of death, is a global health concern. Research stimulated by the dismal prognosis of HCC has led to significant advances in the understanding of its aetio-pathogenesis. Dysregulation of genetic, epigenetic and signalling pathways as well as tumour immunological escape mechanisms are implicated in the development of HCC. This review summarises the current knowledge of these mechanisms and argues that it is only through further understanding of their role in hepatocarcinogenesis, that new effective therapies can be developed

Authors' affiliations

M Setshedi, Department of Medicine, University of Cape Town, Observatory, South Africa;MRC HIU, Weatherall Institute of Molecular Medicine, University of Oxford, United Kingdom

M Andersson, Division of Medical Virology, Department of Pathology, Stellenbosch University, Tygerberg, Cape Town, South Africa; Oxford University Hospitals NHS Foundation Trust, Medical Microbiology and Virology, Oxford, United Kingdom

M M Kgatle, Department of Medicine, University of Cape Town, Observatory, South Africa; Department of Biochemistry, University of Oxford, United Kingdom

L Roberts, Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN, USA

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Cite this article

South African Medical Journal 2018;108(8b):41-46. DOI:10.7196/SAMJ.2018.v108i8b.13500

Article History

Date submitted: 2018-08-08
Date published: 2018-08-08

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