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Kaposi’s sarcoma: Good outcome with doxorubicin, bleomycin and vincristine sulphate (ABV) chemotherapy and highly active antiretroviral therapy

P B Hesseling, E Katayi, P Wharin, R Bardin, F Kouya, D Palmer, M Glenn, M Kruger

Abstract


There is little published information on effective treatment of Kaposi’s sarcoma (KS) in children in low-income countries. We prospectively treated 12 patients with an institutional review board-approved protocol consisting of four monthly courses of doxorubicin (Adriamycin), bleomycin and vincristine sulphate (ABV), with highly active antiretroviral therapy (HAART) plus co-trimoxazole prophylaxis for those who were HIV-positive, with additional vincristine if remission was not achieved after 4 months. Maintenance HAART plus co-trimoxazole was given to all HIV-positive patients. A fine-needle aspirate and CD4+ count were done if possible, and staging was performed according to Mitsuyasu. Eight of ten HIV-positive patients with stage III - IVB disease, and both HIV-negative patients with stage I disease, were in remission after 473 - 1 490 (mean 939) days. One patient died after absconding during treatment, and one died from neutropenia-related pulmonary infection. ABV with or without HAART is an effective treatment option for children with KS.


Authors' affiliations

P B Hesseling, Department of Paediatrics and Child Health, Tygerberg Children’s Hospital and Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa

E Katayi, Cameroon Baptist Convention Health Board, Bamenda, Cameroon

P Wharin, Beryl Thyer Memorial Africa Trust, Warkton, UK

R Bardin, Cameroon Baptist Convention Health Board, Bamenda, Cameroon

F Kouya, Cameroon Baptist Convention Health Board, Bamenda, Cameroon

D Palmer, Cameroon Baptist Convention Health Board, Bamenda, Cameroon

M Glenn, Cameroon Baptist Convention Health Board, Bamenda, Cameroon

M Kruger, Department of Paediatrics and Child Health, Tygerberg Children’s Hospital and Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa

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Keywords

Kaposi’s sarcoma; HAART; Highly active antiretroviral therapy; ABV; Doxorubicin, bleomycin and vincristine sulphate

Cite this article

South African Medical Journal 2017;107(11):952-953. DOI:10.7196/SAMJ.2017.v107i11.12559

Article History

Date submitted: 2017-10-31
Date published: 2017-10-31

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