Recommendations

Appropriate indications for positron emission tomography/computed tomography, 2015

Mariza Vorster, Alexia Doruyter, Anita Brink, Sonto Mkhize, Jen Holness, Nico Malan, Nozipho Nyakale, James M Warwick, Mike Sathekge

Abstract


These recommendations are intended to serve an important and relevant role in advising referring physicians on the appropriate use of 18F-fluorodeoxyglucose (18F-FDG) and non-18F-FDG positron emission tomography/computed tomography (PET/CT), which can be a powerful tool in patient management in oncology, cardiology, neurology and infection/inflammation. PET is a non-invasive molecular imaging tool that provides tomographic images and quantitative parameters of perfusion, cell viability, proliferation and/or metabolic activity of tissues. These images result from the use of different substances of biological interest (sugars, amino acids, metabolic precursors, hormones) labelled with positron-emitting radionuclides (PET radiopharmaceuticals). Fusion of the aforementioned important functional information with the morphological detail provided by CT as PET/CT provides clinicians with a sensitive and accurate one-step whole-body diagnostic and prognostic tool, which directs and changes patient management. Hence PET/CT is currently the most widely used molecular imaging technology for a patient-tailored treatment approach. In these recommendations we outline which oncological and non-oncological indications are appropriate for PET/CT. Once each combination of pathology and clinical indication is defined, a recommendation is given as: 1. Recommended; 2. Recommended in select cases; 3. May be considered; or 4. Not recommended. 


Authors' affiliations

Mariza Vorster, Department of Nuclear Medicine, Steve Biko Academic Hospital and Faculty of Health Sciences, University of Pretoria, South Africa

Alexia Doruyter, Division of Nuclear Medicine, Tygerberg Academic Hospital and Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, Cape Town, South Africa

Anita Brink, Red Cross War Memorial Children’s Hospital, Cape Town; Division of Nuclear Medicine, Department of Paediatrics, Faculty of Health Sciences, University of Cape Town, South Africa

Sonto Mkhize, Division of Nuclear Medicine, Charlotte Maxeke Johannesburg Academic Hospital and Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa

Jen Holness, Division of Nuclear Medicine, Tygerberg Academic Hospital and Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, Cape Town, South Africa

Nico Malan, Division of Nuclear Medicine, Charlotte Maxeke Johannesburg Academic Hospital and Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa

Nozipho Nyakale, Division of Nuclear Medicine, Charlotte Maxeke Johannesburg Academic Hospital and University of the Witwatersrand, Johannesburg, South Africa

James M Warwick, Division of Nuclear Medicine, Tygerberg Academic Hospital and Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, Cape Town, South Africa

Mike Sathekge, Department of Nuclear Medicine, Steve Biko Academic Hospital and University of Pretoria, South Africa

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Keywords

Positron emission tomography/computed tomography; Indications

Cite this article

South African Medical Journal 2016;106(1):105-122. DOI:10.7196/SAMJ.2016.v106i1.10181

Article History

Date submitted: 2015-10-08
Date published: 2015-10-16

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